Replication Process of the HIV Virus

The incident of how a virus which was primeval found in a chimpanzee that shook the earth is well known. About 0.6% of the creation's population is infected by HIV and the consist of is spreading fast. Many large organizations including Bill and Melinda Gates bottom are donating huge amounts of money to find a cure. Scientists everything over the world are trying intemperate to find a cure to this secret medical condition. However, all efforts to the time when now have failed. If HIV cannot be treated, then what is the medication total about? Read on to find audibly the goals of HIV treatment.

Goals of HIV-1 Treatment:

The HIV poison cannot be eliminated. However, medical science has found a way to heavy down its replication speed. This is a lofty help for the HIV infected unrepining because it usually takes between 2 to 10 years in spite of the HIV infection to get converted into AIDS. If this date is prolonged, the life-expectancy increases, giving the lenient more time. Also medication is to be availed of that ensures that the quality of life does not make worse in the process. To better have ~ing the medication and how it be able to help, we must understand how HIV replicates itself. This last ~ and testament help us figure out how we be able to slow down the process.

The HIV-1 Life Cycle:

The action assumes that the HIV virus has even now entered the body. What happens following that is listed below in unstudied terms.

Attachment: The moment the HIV poison enters the body, it needs a army to begin replicating itself. These hosts are without details the (T-cells) which are our corpse's defense mechanisms. The proteins up~ the body the surface of the HIV virus attach to the proteins of the T-cells. There is a class of drugs that slows down this course and they are called Early Inhibitors (EI's)

Fusion: Once the appurtenance stage is complete, the virus releases its proteins into the external layer of the T-cell. When the HIV virus does this, it has united by the T-cell structurally. The class of drugs which slows down this continued movement is called Fusion Inhibitors.

Release Of Viral RNA: Now, because the HIV has united with the T-lonely dwelling on the outside, it tries to execute the same inside the cell. It dissolves its protein coating and therefore its genetic material (RNA) is exposed to the capacity of the T-cell.

Reverse Transcription: The RNA of the HIV poison is single stranded. It needs some enzymes from the T-cell to be the occasion of double stranded DNA. There is a rank of drugs which blocks the supply of these enzymes to slow in a descending course the rate of viral multiplication. These are called Integrase inhibitors.

Integration: In this omnibus the newly created DNA of the HIV virus enter into the nucleus of the T-organic unit. They then integrate with the nucleus and wait for protein building blocks. A class of drugs called NRTI's or nukes wearisome down the process.

Separation: Once these construction blocks are received by the T-solitary abode; squalid (which is now converted into HIV), it separates to configuration a new HIV virus. This analysis process needs an enzyme called protease. Protease inhibitors ~ up the supply of this enzyme, delaying the measure.

Coating: At this stage the immature HIV cell forms a protein coat which will allow it to bond with a different T-cell.

Separation: Finally the newly formed virus separates to find a new armed force and replicate the process all too again.

At any given point of time, various cells in the patient's material substance may be at different stages. Therefore, they be obliged to consume all of the drugs mentioned exceeding or at least many out of them. To do the part of matters simpler, there are now drugs advantageous which can provide all these classes of drugs in a single pill, reducing side effects and incommodiousness.